RenardV1, Main, Exploration, bibRecord, 000621

Analysis of vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) after oral rabies vaccination campaigns in Germany and Austria

Identifieur interne : 000621 ( Main/Exploration ); précédent : 000620; suivant : 000622

Analysis of vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) after oral rabies vaccination campaigns in Germany and Austria

Auteurs : Thomas Muller [Allemagne] ; H.-J. B Tza [Allemagne] ; A. Beckert [Allemagne] ; C. Bunzenthal [Allemagne] ; J. H. Cox [Allemagne] ; C. M. Freuling [Allemagne] ; A. R. Fooks [Royaume-Uni] ; J. Frost [Allemagne] ; L. Geue [Allemagne] ; A. Hoeflechner [Autriche] ; D. Marston [Royaume-Uni] ; A. Neubert [Allemagne] ; L. Neubert [Allemagne] ; S. Revilla-Fernindez [Autriche] ; E. Vanek [Autriche] ; A. Vos [Allemagne] ; E. Wodak [Autriche] ; K. Zimmer [Allemagne] ; T. C. Mettenleiter [Allemagne]

Source :

Archives of virology [ 0304-8608 ] ; 2009.

RBID : Pascal:09-0344143

Descripteurs français

Pascal (Inist)
- Virus associé, Virus rage, Vulpes vulpes, Vaccin, Vaccination, Allemagne, Autriche, Rage.
Wicri :
- geographic : Allemagne, Autriche.
- topic : Vaccin, Vaccination, Rage.

English descriptors

KwdEn :
- Associated virus, Austria, Germany, Rabies, Rabies virus, Vaccination, Vaccine, Vulpes vulpes.

Abstract

To eradicate rabies in foxes, almost 97 million oral rabies vaccine baits have been distributed in Germany and Austria since 1983 and 1986, respectively. Since 2007, no terrestrial cases have been reported in either country. The most widely used oral rabies vaccine viruses in these countries were SAD (Street Alabama Dufferin) strains, e.g. SAD B19 (53.2%) and SAD P5/88 (44.5%). In this paper, we describe six possible vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) detected during post-vaccination surveillance from 2001 to 2006, involving two different vaccines and different batches. Compared to prototypic vaccine strains, full-genome sequencing revealed between 1 and 5 single nucleotide alterations in the L gene in 5 of 6 SAD isolates, resulting in up to two amino acid substitutions. However, experimental infection of juvenile foxes showed that those mutations had no influence on pathogenicity. The cases described here, coming from geographically widely separated regions, do not represent a spatial cluster. More importantly, enhanced surveillance showed that the vaccine viruses involved did not become established in the red fox population. It seems that the number of reported vaccine virus-associated rabies cases is determined predominantly by the intensity of surveillance after the oral rabies vaccination campaign and not by the selection of strains.

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Analysis of vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) after oral rabies vaccination campaigns in Germany and Austria</title>
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<author><name sortKey="Freuling, C M" sort="Freuling, C M" uniqKey="Freuling C" first="C. M." last="Freuling">C. M. Freuling</name>
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<author><name sortKey="Frost, J" sort="Frost, J" uniqKey="Frost J" first="J." last="Frost">J. Frost</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Landesbetrieb Hessisches Landeslabor</s1>
<s2>35392 Giessen</s2>
<s3>DEU</s3>
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<country>Allemagne</country>
<wicri:noRegion>35392 Giessen</wicri:noRegion>
<wicri:noRegion>Landesbetrieb Hessisches Landeslabor</wicri:noRegion>
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</author>
<author><name sortKey="Geue, L" sort="Geue, L" uniqKey="Geue L" first="L." last="Geue">L. Geue</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, WHO Collaborating Centre for Rabies Surveillance and Research</s1>
<s2>16868 Wusterhausen</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>Allemagne</country>
<wicri:noRegion>16868 Wusterhausen</wicri:noRegion>
<wicri:noRegion>WHO Collaborating Centre for Rabies Surveillance and Research</wicri:noRegion>
<wicri:noRegion>16868 Wusterhausen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoeflechner, A" sort="Hoeflechner, A" uniqKey="Hoeflechner A" first="A." last="Hoeflechner">A. Hoeflechner</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Federal Ministry of Health, Family and Youth, Directorate Animal Welfare, Animal Disease and Zoonosis Control</s1>
<s2>1031 Vienna</s2>
<s3>AUT</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
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<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
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</author>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Veterinary Laboratories Agency, Weybridge, WHO Collaborating Centre for the Characterization of Rabies and Rabies-Related Viruses</s1>
<s2>Addlestone, Surrey KT15 3NB</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Addlestone, Surrey KT15 3NB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Neubert, A" sort="Neubert, A" uniqKey="Neubert A" first="A." last="Neubert">A. Neubert</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>IDT Biologika GmbH</s1>
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<s3>DEU</s3>
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<sZ>13 aut.</sZ>
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<country>Allemagne</country>
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<wicri:noRegion>IDT Biologika GmbH</wicri:noRegion>
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<author><name sortKey="Neubert, L" sort="Neubert, L" uniqKey="Neubert L" first="L." last="Neubert">L. Neubert</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>IDT Biologika GmbH</s1>
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<s3>DEU</s3>
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<country>Allemagne</country>
<wicri:noRegion>06861 Dessau-Rosslau</wicri:noRegion>
<wicri:noRegion>IDT Biologika GmbH</wicri:noRegion>
<wicri:noRegion>IDT Biologika GmbH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Revilla Fernindez, S" sort="Revilla Fernindez, S" uniqKey="Revilla Fernindez S" first="S." last="Revilla-Fernindez">S. Revilla-Fernindez</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Agency for Food and Health Safety GmbH, Department of Veterinary Medicine, Institute for Veterinary Disease Control</s1>
<s2>2340 Mödling</s2>
<s3>AUT</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>2340 Mödling</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vanek, E" sort="Vanek, E" uniqKey="Vanek E" first="E." last="Vanek">E. Vanek</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Agency for Food and Health Safety GmbH, Department of Veterinary Medicine, Institute for Veterinary Disease Control</s1>
<s2>2340 Mödling</s2>
<s3>AUT</s3>
<sZ>14 aut.</sZ>
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<sZ>17 aut.</sZ>
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<country>Autriche</country>
<wicri:noRegion>2340 Mödling</wicri:noRegion>
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</author>
<author><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A." last="Vos">A. Vos</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>IDT Biologika GmbH</s1>
<s2>06861 Dessau-Rosslau</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>06861 Dessau-Rosslau</wicri:noRegion>
<wicri:noRegion>IDT Biologika GmbH</wicri:noRegion>
<wicri:noRegion>IDT Biologika GmbH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wodak, E" sort="Wodak, E" uniqKey="Wodak E" first="E." last="Wodak">E. Wodak</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Agency for Food and Health Safety GmbH, Department of Veterinary Medicine, Institute for Veterinary Disease Control</s1>
<s2>2340 Mödling</s2>
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<sZ>14 aut.</sZ>
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<country>Autriche</country>
<wicri:noRegion>2340 Mödling</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zimmer, K" sort="Zimmer, K" uniqKey="Zimmer K" first="K." last="Zimmer">K. Zimmer</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department Veterinary Medicine, Landesuntersuchungsamt Rhineland Palatinate</s1>
<s2>56073 Koblenz</s2>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>56073 Koblenz</wicri:noRegion>
<wicri:noRegion>Landesuntersuchungsamt Rhineland Palatinate</wicri:noRegion>
<wicri:noRegion>56073 Koblenz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mettenleiter, T C" sort="Mettenleiter, T C" uniqKey="Mettenleiter T" first="T. C." last="Mettenleiter">T. C. Mettenleiter</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health</s1>
<s2>17493 Greifswald, Insel Riems</s2>
<s3>DEU</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Insel Riems</wicri:noRegion>
<wicri:noRegion>Federal Research Institute for Animal Health</wicri:noRegion>
<wicri:noRegion>17493 Greifswald, Insel Riems</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Archives of virology</title>
<title level="j" type="abbreviated">Arch. virol.</title>
<idno type="ISSN">0304-8608</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Archives of virology</title>
<title level="j" type="abbreviated">Arch. virol.</title>
<idno type="ISSN">0304-8608</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Associated virus</term>
<term>Austria</term>
<term>Germany</term>
<term>Rabies</term>
<term>Rabies virus</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Vulpes vulpes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus associé</term>
<term>Virus rage</term>
<term>Vulpes vulpes</term>
<term>Vaccin</term>
<term>Vaccination</term>
<term>Allemagne</term>
<term>Autriche</term>
<term>Rage</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term>
<term>Autriche</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
<term>Vaccination</term>
<term>Rage</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To eradicate rabies in foxes, almost 97 million oral rabies vaccine baits have been distributed in Germany and Austria since 1983 and 1986, respectively. Since 2007, no terrestrial cases have been reported in either country. The most widely used oral rabies vaccine viruses in these countries were SAD (Street Alabama Dufferin) strains, e.g. SAD B19 (53.2%) and SAD P5/88 (44.5%). In this paper, we describe six possible vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) detected during post-vaccination surveillance from 2001 to 2006, involving two different vaccines and different batches. Compared to prototypic vaccine strains, full-genome sequencing revealed between 1 and 5 single nucleotide alterations in the L gene in 5 of 6 SAD isolates, resulting in up to two amino acid substitutions. However, experimental infection of juvenile foxes showed that those mutations had no influence on pathogenicity. The cases described here, coming from geographically widely separated regions, do not represent a spatial cluster. More importantly, enhanced surveillance showed that the vaccine viruses involved did not become established in the red fox population. It seems that the number of reported vaccine virus-associated rabies cases is determined predominantly by the intensity of surveillance after the oral rabies vaccination campaign and not by the selection of strains.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Autriche</li>
<li>Royaume-Uni</li>
</country>
<region><li>District de Cologne</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Vienne (Autriche)</li>
</region>
<settlement><li>Bonn</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Muller, Thomas" sort="Muller, Thomas" uniqKey="Muller T" first="Thomas" last="Muller">Thomas Muller</name>
</noRegion>
<name sortKey="B Tza, H J" sort="B Tza, H J" uniqKey="B Tza H" first="H.-J." last="B Tza">H.-J. B Tza</name>
<name sortKey="Beckert, A" sort="Beckert, A" uniqKey="Beckert A" first="A." last="Beckert">A. Beckert</name>
<name sortKey="Bunzenthal, C" sort="Bunzenthal, C" uniqKey="Bunzenthal C" first="C." last="Bunzenthal">C. Bunzenthal</name>
<name sortKey="Cox, J H" sort="Cox, J H" uniqKey="Cox J" first="J. H." last="Cox">J. H. Cox</name>
<name sortKey="Freuling, C M" sort="Freuling, C M" uniqKey="Freuling C" first="C. M." last="Freuling">C. M. Freuling</name>
<name sortKey="Frost, J" sort="Frost, J" uniqKey="Frost J" first="J." last="Frost">J. Frost</name>
<name sortKey="Geue, L" sort="Geue, L" uniqKey="Geue L" first="L." last="Geue">L. Geue</name>
<name sortKey="Mettenleiter, T C" sort="Mettenleiter, T C" uniqKey="Mettenleiter T" first="T. C." last="Mettenleiter">T. C. Mettenleiter</name>
<name sortKey="Neubert, A" sort="Neubert, A" uniqKey="Neubert A" first="A." last="Neubert">A. Neubert</name>
<name sortKey="Neubert, L" sort="Neubert, L" uniqKey="Neubert L" first="L." last="Neubert">L. Neubert</name>
<name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A." last="Vos">A. Vos</name>
<name sortKey="Zimmer, K" sort="Zimmer, K" uniqKey="Zimmer K" first="K." last="Zimmer">K. Zimmer</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Fooks, A R" sort="Fooks, A R" uniqKey="Fooks A" first="A. R." last="Fooks">A. R. Fooks</name>
</noRegion>
<name sortKey="Marston, D" sort="Marston, D" uniqKey="Marston D" first="D." last="Marston">D. Marston</name>
</country>
<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Hoeflechner, A" sort="Hoeflechner, A" uniqKey="Hoeflechner A" first="A." last="Hoeflechner">A. Hoeflechner</name>
</region>
<name sortKey="Revilla Fernindez, S" sort="Revilla Fernindez, S" uniqKey="Revilla Fernindez S" first="S." last="Revilla-Fernindez">S. Revilla-Fernindez</name>
<name sortKey="Vanek, E" sort="Vanek, E" uniqKey="Vanek E" first="E." last="Vanek">E. Vanek</name>
<name sortKey="Wodak, E" sort="Wodak, E" uniqKey="Wodak E" first="E." last="Wodak">E. Wodak</name>
</country>
</tree>
</affiliations>
</record>

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Analysis of vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) after oral rabies vaccination campaigns in Germany and Austria

Analysis of vaccine-virus-associated rabies cases in red foxes (Vulpes vulpes) after oral rabies vaccination campaigns in Germany and Austria

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